Chicago Transit - 121 Schedule
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Monday-Friday - Union Station
| McClurg Ct & Huron St | Fairbanks Ct & Huron St | Adams St & Canal St | Jackson Blvd & Canal St |
| 6:46am | - | 7:00am | 7:03am |
| 7:05am | - | 7:21am | 7:24am |
| 7:24am | - | 7:42am | 7:44am |
| 7:43am | - | 8:02am | 8:04am |
| 8:01am | - | 8:21am | 8:23am |
| 8:19am | - | 8:39am | 8:41am |
| 8:38am | - | 8:58am | 9:00am |
| 8:57am | - | 9:17am | - |
| 9:16am | - | 9:34am | - |
| 9:35am | - | 9:53am | - |
| - | 3:40pm | 4:00pm | - |
| - | 3:55pm | 4:15pm | 4:18pm |
| - | 4:06pm | 4:28pm | 4:30pm |
| - | 4:16pm | 4:39pm | 4:42pm |
| - | 4:25pm | 4:51pm | - |
| - | 4:35pm | 5:00pm | 5:03pm |
| - | 4:45pm | 5:11pm | - |
| - | 4:55pm | 5:20pm | 5:23pm |
| - | 5:05pm | 5:31pm | - |
| - | 5:15pm | 5:39pm | - |
| - | 5:25pm | 5:48pm | 5:50pm |
| - | 5:35pm | 5:57pm | - |
| - | 5:46pm | 6:07pm | - |
| - | 5:59pm | 6:19pm | - |
| - | 6:15pm | 6:33pm | - |
Monday-Friday - Northwestern University, Chicago
| Jackson Blvd & Canal St | McClurg Ct & Huron St | Fairbanks Ct & Chicago Ave |
| 6:40am | - | 6:56am |
| 6:55am | - | 7:11am |
| 7:09am | - | 7:26am |
| 7:23am | - | 7:40am |
| 7:34am | - | 7:51am |
| 7:44am | - | 8:02am |
| 7:54am | - | 8:12am |
| 8:04am | - | 8:22am |
| 8:14am | - | 8:32am |
| 8:24am | - | 8:42am |
| 8:34am | - | 8:52am |
| 8:46am | - | 9:04am |
| 9:00am | - | 9:17am |
| 9:15am | - | 9:32am |
| 4:03pm | 4:18pm | - |
| 4:23pm | 4:38pm | - |
| 4:41pm | 4:57pm | - |
| 4:58pm | 5:15pm | - |
| 5:17pm | 5:34pm | - |
| 5:36pm | 5:52pm | - |
| 5:56pm | 6:12pm | - |